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There are many misconceptions about clinical research, so we have unpacked a few common myths we hear to help you make an informed decision in your healthcare. Misconception #1: If I join a clinical trial, I’ll just be a guinea pig. Quite the opposite is true! Through honest and respectful conversation, we ensure all participants are informed of the benefits and risks associated with the clinical trial during the informed consent process. Being in a clinical trial is voluntary, and we respect our patients’ decision to join or decline to participate in the clinical trial. You can always change your mind at any time as well. When patients join a clinical trial, they receive an additional team of healthcare professionals, including additional physicians, pharmacists and research coordinators, dedicated to their safety and well-being. This means that clinical trial participants often receive more support than they would in the standard treatment setting. Misconception #2: Clinical trials are too dangerous because they use new treatments that haven’t been tested. We recognize that there are different levels of risk associated with participating in a clinical trial depending on the type of study. However, new treatments are only reviewed through clinical trials after they have gone through extensive testing. New treatments that do not show promising results for safety and potential benefit during laboratory testing do not receive approval to begin clinical trials. Your research team reviews any expected benefits and risks identified from previous studies during the informed consent process, as well as any updates that occur throughout the duration of the clinical trial. The research team stays in close contact with you during the entire process, documenting and treating any side effects that you experience for both your safety and the safety of participants like you. Misconception #3: I don't want to join a trial because I could be wasting my time receiving a placebo. A placebo is a substance that has no therapeutic effect, sometimes called a “sugar pill.” Participants who receive a placebo during a clinical trial are very important, helping researchers definitively determine the specific good and bad effects of the new medication. Many clinical trials that involve a placebo also offer what is called an open label extension or cross-over study. Cross-over studies ensure that anyone taking the placebo can begin receiving the new medication, often for several years. Cross-over studies help clinician researchers understand the long-term effects of a medication while also giving patients free access to novel care for several months and even years.

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Participating in a clinical trial is voluntary and a personal choice. Clinical trials are research studies that involve people and are an important part of patient care. What is a clinical trial?  Clinical trials are research studies that involve people, and they are an important part of patient care. There are several different types of clinical trials; some are designed to understand trends in a disease or identify better ways to diagnose a condition, while others determine if a new treatment is safe and works when treating, improving or preventing a health condition. There are over 400,000 clinical trials currently being conducted in the United States, and even more across the world. This includes health conditions such as heart failure, cancer, Parkinson’s Disease, respiratory conditions like COPD, common infections, cystic fibrosis, and many more. Clinical trials lead the healthcare industry to new discoveries that contribute to reliable and exact care, improving healthcare quality and saving lives. Clinical trials are conducted by a team of researchers, including doctors, pharmacists and clinical research coordinators. These research teams are highly skilled in their specialty areas, often providing traditional patient care and seeing research patients in the same day. These teams are responsible for making sure the clinical trial is completed correctly, and their patients are their top priority. Why should I consider participating in a clinical trial? Participating in a clinical trial is voluntary and a personal choice. There are many reasons why patients decide to get involved in clinical research. While many clinical trials are designed for patients who have a certain health condition, many studies also ask healthy volunteers to contribute in order to compare health outcomes. Clinical trials are also for patients at all different stages of their diagnosis. Depending on the specific study, the patient may receive access to a new cutting-edge treatment before it is widely available. When patients join a clinical trial, the research team becomes a health partner dedicated to their health and well-being. When patients join a clinical trial, they make an informed decision in their healthcare by weighing all available options in addition to routine treatments. Research participants know that they are contributing meaningfully and helping other patients like them. Where can I find more information about clinical trials at Renown Health? Renown Health’s mission is to make a genuine difference in the health and well-being of the communities we serve. Renown’s clinical trial portfolio offers leading care options to patients in northern Nevada, close to home, in a variety of specialties. Contact the Renown Clinical Research Office for more information on clinical trials available to you!

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Renown Health, the region's leading cardiology care provider, is offering a clinical trial for eligible patients struggling to control their high blood pressure. Nearly half of adults (119.9 million) in the United States have hypertension, or blood pressure that is higher than normal. Hypertension can put you at risk of other life-threatening disease, such as a heart attack or stroke. There are methods that cardiologists use to manage high blood pressure, but only 1 in 4 adults with hypertension (27.0 million) have their blood pressure under control.* Some patients with high blood pressure experience resistant hypertension, which does not respond well to multiple antihypertensive medications given at the same time. This means that there are many important opportunities for healthcare professionals to explore new ways to treat hypertension.  At Renown Health, we lead the region in cardiology care with our technological expertise and patient-centered approach. That is why our cardiology team is partnering with the Renown Research Office to offer the RADIANCE Continued Access Protocol (RADIENCE CAP) clinical trial to eligible patients. RADIANCE CAP is a non-randomized study designed to allow for continued access to ultrasound renal denervation therapy via the Paradise System, and to allow for the on-going collection of safety and effectiveness data in patients with uncontrolled hypertension despite the prescription of antihypertensive medications. The body’s complex communication system between the brain, heart and kidneys can sometimes become overactive, increasing your blood pressure through messages in the nervous system. Renal denervation is a minimally-invasive procedure which reduces activity from the nerves in your kidneys to lower blood pressure.  This is the third in a series of renal denervation clinical trials Renown Health has offered to patients with resistant hypertension over the last several years, with over 40 local participants.  “All the participants that I have had the pleasure to work with on these studies are very excited and grateful to have this option for helping control their blood pressure” states Lisa English, Lead Clinical Research Coordinator for Cardiology studies at Renown Health. “I love getting to know each one of them and helping on their healthcare journey. We have an amazing team of providers and staff at Renown that go out of their way to make patients experiences positive and the studies successful.” Dr. Michael Bloch, Cardiologist and Principal Investigator for the RADIANCE CAP study at Renown Health’s Institute for Heart and Vascular Health adds, “Despite lifestyle modifications like diet and exercise and the widespread availability of effective and well-tolerated medications, approximately 50% of all people with hypertension have inadequate blood pressure control putting them at risk for stroke, heart failure and kidney disease. As a one-time durable procedure, renal denervation with the Paradise endovascular system from ReCor Medical, Inc. may help millions of patients improve their blood pressure control without necessarily needing to increase their medications.” Our teams of expert providers and researchers are here to support you on your healthcare journey. Talk to your provider about the RADIANCE CAP clinical trial at your next appointment to see if participation may be right for you.

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Every year, 16,000 children face the daunting diagnosis of cancer, and what might surprise you is that almost 90% of them receive treatment at institutions affiliated with the Children's Oncology Group (COG). Renown Children’s Hospital, a member of COG since 2020, plays a vital role in this transformative journey. Just half a century ago, childhood cancer was a near-incurable challenge, but today, thanks to the groundbreaking research led by COG, the survival rate over a five-year period has soared to an inspiring 80%. “The standard of care continues to advance, particularly with cancer, as more research is conducted and additional treatment options become available,” said Kristen Gurnea, Manager of Clinical Research at Renown Health. “Our community can contribute to these advancements through COG for the benefit of both individual patients and the entire population joined together in the fight against pediatric cancer. We are proud to contribute to that mission.” As a member of the world's largest organization devoted exclusively to childhood cancer research, Renown recognizes the joint efforts from researchers and patients alike and is proud to aid in reaching this goal in partnership with COG and our very own northern Nevada community.

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There are nearly 1 million adults living with MS in the United States alone. For comparison, that is roughly the entire population of the Reno/Sparks and Las Vegas areas combined. MS is a neurological autoimmune condition which means that the immune system of patients with MS attacks the body’s myelin, a protective substance that covers your nerves. When this happens, the unprotected nerves can be damaged. Patients with MS may experience many different symptoms ranging from mild to severe, such as mobility and vision problems, fatigue and difficulty thinking. MS is usually diagnosed between the ages of 20-50, but late onset MS can occur in patients over 50 years old. While there is no cure for MS, there are effective treatments that can help reduce the burden of patients’ symptoms and create a positive quality of life. At Renown Health, we have joined the fight against MS through a partnership between advanced neurology programs and providers and our research office. We are proud to offer newly diagnosed MS patients the opportunity to choose between standard care treatment options or participating in an open label clinical trial, the AGNOS study. This study is assessing the impact of a new medication, ofatumumab, as the first disease modifying therapy participants receive for managing relapsing remitting MS, the most common form of MS.

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Jason Farnsworth, Evan Fox and Jennifer Jenni are three of Renown’s more than 500 employees who currently serve, or who have served, in our miliary. Their deep-rooted passion for helping our community extends to the Nevada National Guard (NANG), an organization that shares many values with Renown. We sat down with Jason, Evan and Jenni to ask their perspective on what propels them to serve people in our home state and learn more about how Renown's partnership with the Nevada National Guard has supported their personal and professional growth. Meet Jason Farnsworth, the Face Behind Renown’s Partnership with the National Guard Jason Farnsworth is the Director of Respiratory Care Services at Renown and the Chief Master Sergeant, Medical Superintendent of the Nevada National Guard. He has been with the Guard and Renown for 23 years. Jason joined the Guard over 20 years ago to help pay for his college education. After using up his paid vacation time from Renown for Guard events like deployments or training in his initial years as a Guard member, Jason approached Renown senior leadership with the idea of paid military leave. “In full support of employees who choose to serve, Renown stepped up to give a resounding, ‘yes,’ as they have time and time again for our military community,” Jason said. From that day forward, policies were implemented at Renown to further support individuals who serve our country with paid military leave. As a result, Jason submitted an Employer Support of the Guard and Reserve (ESGR) Secretary of Defense Freedom Award nomination and Renown Health won the highest-level department of defense employer recognition in the nation. Since then, Jason has received four associate degrees, one bachelor’s degree and a master’s degree with the government’s support and has been promoted several times to his current roles at Renown and the Guard. “As I progressed at Renown, I was able to progress in the National Guard. They've complimented one another on leadership skills and clinical competencies.” How Evan Fox Finds Synergy in His Roles at Renown and the National Guard After five years as a cardiac intensive care unit (ICU) nurse at Renown Regional Medical Center and two years as a First Lieutenant Critical Care Nurse in the Guard, Evan Fox has implemented care plans for many community members and put his expertise to good use. The countless trauma hours he has completed at Renown have directly translated to the field as a Guard member. He states that “his roles are synergistic, and his innumerable hours of critical care are worth their weight in gold because of the transferability between the two positions.” Evan’s Roles Provide Service to Our Community, and Beyond Evan feels passionately that his experience with the Guard is unique because you live in the area that you serve, whereas with other military branches you are often stationed elsewhere. Recently, he’s cared for many people involved in firefighting missions in our surrounding areas. As a member of the medical group of the Nevada National Guard, Evan is prepared to provide critical care at any given moment in the event of deployment due to a natural or man-made disaster. He can provide critical care in our region and across the nation. How Jennifer’s Leadership Journey Continues to Grow Jennifer Jenni is the nurse manager of the cardiac ICU and intermediate care unit at Renown Regional Medical Center. She has been with Renown for 13 years and initially started at Renown South Meadows Medical Center in the general surgical unit. She felt compelled to take advantage of Renown’s development programs as she worked her way up to supervisor and now as a manager. She is also a registered nurse and captain in the Nevada National Guard as well as a member of an enhanced resource force team, equipped to provide aid anywhere in the nation in the event of a disaster. With Jennifer, People Always Come First Her dedication to serving people has always been a part of who she is, even before she became a leader. From an early age, Jennifer felt strongly that she wanted to be involved in the military in some way stating that “the Guard is very much a service to the people, whether it's our community or nationwide.” While her clinical leadership qualities and skills have translated well to her role as a captain, holding two leadership titles is no easy feat – especially when it comes to the continued training her roles require. However, because of the support Renown provides its military community, Jennifer was able to confidently attend officer training in Alabama last year. Jennifer was fully supported by her Renown team when she was away and took advantage of her paid military leave benefit. More Than Just a Partnership, but a Family Jason, Evan and Jennifer are among the many employees who choose to serve both here at Renown and in the Guard. You might see National Guard members who are also Renown employees in areas like the cardiac ICU, trauma ICU, emergency department or medics who work on hospital floors. “Not only is my family out at the National Guard, but they are also here at Renown. It’s amazing to see how many people spend their lives giving back,” Jason said.

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Most babies weigh just one pound and are roughly the size of an eggplant when they reach 24 weeks of development inside the womb. It is a crucial stage when internal organs begin functioning, and the babies' respiratory and central nervous systems are still developing.     So, in November 2021 when Kallie Johnson experienced a premature rupture of amniotic fluid around this point in her pregnancy, her care team in Winnemucca decided to transport her via Care Flight to Renown Regional Medical Center. The team at Renown Children’s Hospital immediately began discussing the risks of delivering at 24 weeks with the Johnson family.  Moving Forward with Hope Knowing the stakes, Kallie remembers never feeling rushed to decide about delivering her baby preterm. “I felt educated and supported by my care team at Renown throughout our entire stay, starting with the education they provided about what it meant to deliver my baby early,” Kallie said. “The team really helped me make the best decision for myself and my family.”    Together, Renown employees and the Johnson family moved forward with a healthy set of nerves and a powerful feeling of hope.  Weighing in at one pound 11 ounces, Sloan entered the world on Nov. 19, 2021, via emergency Cesarean section. Her birth was classified as a micro preemie because she was born before week 26 of pregnancy and so small that she fit inside the palm of her father Sterling’s hand. A full-term pregnancy is classified as reaching 39 weeks.   A Fighting Chance  Called a fighter by many Renown Children’s Hospital care team members, Sloan spent over five months in the neonatal intensive care unit (NICU). She was placed on a ventilator, fed through a feeding tube and monitored 24/7, overcoming daily challenges with the Renown team and her family.  As a result of being born prematurely, Sloan developed a grade one brain bleed and a congenital heart defect called patent ductus arteriosus, a persistent opening between two major blood vessels, causing too much blood to flow to the lungs and heart.   To meet the oxygen needs of her tiny lungs, Sloan was intubated and developed a severe oral aversion and high-arched palate as a result. The effects would lead to difficult developmental and physical challenges that she still conquers today. Yet, with the help of her care team – including physical, occupational and speech therapists, dieticians and doctors – Sloan continues to make progress every day.

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