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Research Shows Genetic Approaches to Breast Cancer Screenings Yield More Accurate Results
Clinical researchers with the Healthy Nevada Project co-author research paper with findings that emphasize the need for a comprehensive approach to breast cancer risk assessment – including a focus on genetic medicine – to help ensure that individuals at high risk are identified and supported proactively rather than reactively. Breast cancer is a leading cause of cancer death among women in the United States. According to the American Cancer Society, about 1 in 8 women will develop breast cancer and about 1 in 39 women will die from breast cancer. Breast cancer is associated with increased age, hereditary factors, obesity, and alcohol use. Since 1990, breast cancer death rates have declined progressively due to advancements in treatment and detection. In Nevada there are an estimated 2,310 new breast cancer cases a year, and genetic mutations such as in the genes BRCA1 or BRCA2 remain a top risk factor for this prevalent disease. Recognizing the urgency for progress in breast cancer research, a collaborative effort between physicians, advanced practice providers and scientists from the Healthy Nevada Project® (HNP) and Helix have unveiled groundbreaking research. This study explores how genetic screenings are a necessary supplement to traditional testing methods, together offering more accurate insights into a patient's likelihood of developing breast cancer in the future. HNP is operated by Renown Genomic Medicine and the Institute for Health Innovation and is one of the largest community-based population health studies in the country. Their team works in collaboration with Helix, a leader in precision health that delivers comprehensive genomic solutions. Together, this dynamic partnership aims to understand breast cancer risk factors and pave the way for more effective preventative measures. The combined research team studied 25,591 female HNP participants to evaluate the performance of different genetic screening approaches to identify women at high risk of breast cancer. The results of this research suggest that a combined monogenic, or single-gene, and polygenic, or multi-gene, approach to breast cancer screenings helped produce more accurate results and more closely identify study participants who have a high genetic risk of developing the disease. "Based on this research, we are advocating a shift in approach which would improve breast cancer risk assessment through a combination of effective family history ascertainment and genetic screening,” said Joseph Grzymski, PhD, principal investigator of the Healthy Nevada Project, research professor at the University of Nevada, Reno School of Medicine and co-author of the breast cancer research paper. “This tailored approach, founded on the assessment of individual genetic risk, not only intends to elevate patient well-being but also will improve efficiency and equity in healthcare." Complementing the team’s research on leveraging genetics to identify women at low genetic risk of breast cancer that could safely defer mammogram screenings by five to 10 years that was released in late 2023 in JAMA Oncology, the study suggests that incorporating genetic information can assist in personalizing breast cancer screenings and optimizing the use of screening resources. "Existing disparities persist across various facets of breast cancer screening and treatment; however, genetic screening is clearly a powerful tool to help facilitate early intervention for those at higher risk,” said Jamie Schnell Blitstein, APRN, a primary care nurse practitioner at Renown Health and co-author of the breast cancer research paper. “By placing a heightened focus on risk, we underscore the pivotal role of preventative breast cancer screening.” Despite the availability of effective methods for early screening, co-authors of this research found that 78 percent of women with a family history of breast cancer had their risk ascertained only after a breast cancer diagnosis. The findings emphasize the need for a comprehensive approach to breast cancer risk assessment – including a focus on genetic medicine – to help ensure that individuals at high risk are identified and supported proactively rather than reactively. “These findings that can profoundly impact how healthcare is delivered were only made possible by all the participants who were willing to consent to research,” said Alex Bolze, PhD from Helix and co-author of the publication. “Broad-scale collaboration projects like these between Renown Health and UNR that engage large populations where participants share both their genetic information as well as electronic health records drive advancements in preventative medicine, as well as fundamental biological research.” The research paper was officially accepted on Jan. 29, 2024, and will be published by Elsevier, Inc. on behalf of the American College of Medical Genetics and Genomics. The contents of the paper will appear in the international journal Genetics in Medicine Open. Read the full article by visiting sciencedirect.com. The Healthy Nevada Project is currently recruiting new study participants. Free to all Nevadans with a saliva sample or blood draw, participants and their referring providers receive access to whole-exome sequencing and clinical grade results that help provide insight into their unique genetic risks tied to heart disease and certain cancers. If you are interested in enrolling in the study, schedule a Virtual Consent Appointment through MyChart or contact the Renown Institute for Health Innovation at RenownIHI@renown.org or (775) 982-6914 to be connected to a Genomic Representative. About Renown Health Renown Health is the region’s largest, not-for-profit integrated healthcare network serving Nevada, Lake Tahoe and northeast California. With a diverse workforce of more than 7,000 employees, Renown has fostered a longstanding culture of excellence, determination and innovation. The organization comprises a trauma center, two acute care hospitals, a children’s hospital, a rehabilitation hospital, a medical group and urgent care network, and the region’s largest, locally owned not-for-profit insurance company, Hometown Health. Renown is currently enrolling participants in the largest community-based genetic population health study, the Healthy Nevada Project®. To join the Renown Health team, visit renown.org/careers. About Helix Helix is the leading population genomics and viral surveillance company operating at the intersection of clinical care, research, and data analytics. Helix enables health systems, life sciences companies, payers, and government partners to accelerate the integration of genomic data into patient care and public health decision-making. Learn more at helix.com.
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Head, Neck and Oral Cancers: How You Can Spot and Treat Them
Head, neck and oral cancers account for just 3 percent of all cancer in the U.S. and can be hard to diagnose. Dr. Abhinand Peddada, radiation oncologist with the Renown Institute for Cancer, explains. While you likely don’t frequently hear about head, neck and oral cancers — they are significantly less common than many kinds of cancer — they can be extremely dangerous. One of the primary reasons: some symptoms mimic the common cold, making them difficult to detect without a medical professional. We asked Abhinand Peddada, M.D., radiation oncologist with the Renown Institute for Cancer, to break down the symptoms and lifestyle risks of these rare cancers. First off, what are some of the signs and symptoms of head, neck and oral cancers? Symptoms can vary based on where the cancer is. For example, throat cancer may show up as a persistent sore throat, while sinus cancer may present as soreness or pressure in the sinuses that doesn’t get better. Some other symptoms to watch may include: Swelling in the throat Painless swelling in the neck Red or white patches in the throat Hoarseness Bloody noses or blood in the mucus or saliva A new and unexplained lump or bump anywhere on the face, neck, mouth or throat Difficulty breathing Difficulty swallowing, chewing or moving the muscles in your face, neck, mouth or throat Bad breath, even with good oral hygiene Loose teeth Dentures or retainers that no longer fit Double vision Who is most at risk for head, neck and oral cancers? Both men and women can develop head, neck and oral cancers, but men are at almost twice the risk of women. People over the age of 40 are also at a higher risk, and these cancers tend to be more common in African Americans. Tobacco use — including cigarettes, cigars, pipes and chewing tobacco — is another risk factor. Tobacco is linked to 85 percent of head and neck cancers. Exposure to fumes and chemicals can increase your risk as well. We’re also seeing more HPV-related head and neck cancers in the U.S., so patients with HPV may want to watch more closely for symptoms. What about screening and prevention? Your dentist already looks for signs and symptoms at your regular dental checkups. Additionally, if you have one of these risk factors and are experiencing signs and symptoms, it’s a good idea to check with your doctor about possible screenings. To help prevent these types of cancers, try to minimize your controllable risk factors. This means quitting tobacco, watching your alcohol consumption and taking care of your oral hygiene by brushing and flossing regularly. We also recommend the HPV vaccination for both boys and girls starting at age 11. By vaccinating at an earlier age, one is less likely to develop oral HPV. What do diagnosis and treatment look like for these cancers? At Renown Institute for Cancer we offer the most advanced diagnostic testing available including fiberoptic photos, CT and PET scans, as well as MRIs. Together, you and your care team will decide which treatment best fits your needs. For these types of cancers, treatment options include radiation, chemotherapy and surgery. Renown Institute for Cancer | 775-982-4000 At the Renown Health Institute for Cancer, our experienced team provides the support and care to maintain the highest quality of life and then achieve the best possible outcome, all in one location that’s close to home. Our dedicated team, clinical expertise and advanced treatment options allow us to tailor care to each patient. Learn about: Our Team Cancers We Treat Screening and Prevention Treatment Options Find a Cancer Doctor
Read More About Head, Neck and Oral Cancers: How You Can Spot and Treat Them
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3Dec
Renown Institute for Cancer is teaming up with Renie Anderson, a trained and certified expert in cancer treatment side effect management. Attend this workshop in person at Renown Regional or virtually via Zoom to learn mind-body techniques to help you feel more connected and joyful in life as you move beyond cancer. This workshop includes: Emphasizing the importance of identifying resistance. Moving through resistance by understanding the concepts of acceptance and surrender. Identifying goals and visions. Creating action steps to help break patterns, to help you stay in a healthier mindset and feel more calm. There is no charge to attend this class. Video enabled attendance is available. Patients can access remotely and join from any video-enabled device. To receive the Zoom link to connect to this workshop, please email Renie Anderson @ renieanderson@att.net
Read More About Journey Beyond Your Cancer: Thrivorship Workshop
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11Nov
Renown Institute for Cancer is teaming up with Renie Anderson, a trained and certified expert in cancer treatment side effect management. Attend this workshop in person at Renown Regional or virtually via Zoom to learn mind-body techniques to help reduce stress and fears while caring for your loved one going through treatment. There is relief in knowing you are not alone. This workshop includes: Identifying and talking about fears, resistance and frustrations. Creating end results to help them re-frame the discussion. Learning tools to help identify needs and wants; being able to ask for them so you can refuel and become more available to yourself and your loved ones for the long haul. Learning about the available options. There is no charge to attend this class. Video enabled attendance is available. Patients can access remotely and join from any video-enabled device. To receive the Zoom link to connect to this workshop, please email Renie Anderson @ renieanderson@att.net
Read More About Journey Through Your Cancer and Beyond: Caregiver Workshop
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8May
This class is for anyone who has undergone or is undergoing breast cancer treatment and will focus on lymphedema education and reducing the risk of its occurrence. During the class, we will review the basic anatomy of the lymphatic system and define common procedures performed during the treatment course for breast cancer that affects lymphatics. Risk reduction strategies, including compression sleeves, will be reviewed in addition to the typical presentation of early lymphedema. Finally, a brief description of Axillary Web Syndrome will also be reviewed, and basic stretches/exercises to implement if cording is present.
Read More About Lymphedema Education and Risk Reduction Class
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1Oct
Renown Institute for Cancer is teaming up with Renie Anderson, a trained and certified expert in cancer treatment side effect management. Attend this workshop in person at Renown Regional or virtually via Zoom to learn mind-body techniques to help you feel more connected and joyful in life as you move beyond cancer. This workshop includes: Emphasizing the importance of identifying resistance. Moving through resistance by understanding the concepts of acceptance and surrender. Identifying goals and visions. Creating action steps to help break patterns, to help you stay in a healthier mindset and feel more calm. There is no charge to attend this class. Video enabled attendance is available. Patients can access remotely and join from any video-enabled device. To receive the Zoom link to connect to this workshop, please email Renie Anderson @ renieanderson@att.net
Read More About Cancer Support Virtual Workshop 3: Thrivorship – After Cancer Care
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1Oct
Renown Institute for Cancer is teaming up with Renie Anderson, a trained and certified expert in cancer treatment side effect management. Attend this workshop in person at Renown Regional or virtually via Zoom to learn mind-body techniques to help you feel more connected and joyful in life as you move beyond cancer. This workshop includes: Emphasizing the importance of identifying resistance. Moving through resistance by understanding the concepts of acceptance and surrender. Identifying goals and visions. Creating action steps to help break patterns, to help you stay in a healthier mindset and feel more calm. There is no charge to attend this class. Video enabled attendance is available. Patients can access remotely and join from any video-enabled device. To receive the Zoom link to connect to this workshop, please email Renie Anderson @ renieanderson@att.net
Read More About Journey Beyond Your Cancer: Thrivorship Workshop
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7May
Renown Institute for Cancer is teaming up with Renie Anderson, a trained and certified expert in cancer treatment side effect management. Attend this workshop in person at Renown Regional or virtually via Zoom to learn mind-body techniques to help you feel more connected and joyful in life as you move beyond cancer. This workshop includes: Emphasizing the importance of identifying resistance. Moving through resistance by understanding the concepts of acceptance and surrender. Identifying goals and visions. Creating action steps to help break patterns, to help you stay in a healthier mindset and feel more calm. There is no charge to attend this class. Video enabled attendance is available. Patients can access remotely and join from any video-enabled device. To receive the Zoom link to connect to this workshop, please email Renie Anderson @ renieanderson@att.net
Read More About Journey Beyond Your Cancer: Thrivorship Workshop
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23Sep
Renown Institute for Cancer is teaming up with Cancer Treatment Expert Renie Anderson, who is trained and certified at managing cancer treatment side effects. You can attend this workshop in person at Renown Regional or virtually via Zoom. This workshop teaches mind-body techniques to help reduce anxiety, feel calmer, visualize your treatment in a healing way and enhance healing through activities that will bring you relief. This workshop includes: Helping patients feel more connected, reducing fight/flight response and assisting patients to feel more at ease. Learning how stress impacts our bodies and our role in taking responsibility as a partner in recovery. A mindfulness relaxation session. Allowing patients to express concerns over their side effects and re-framing for a more positive experience. Open time for questions and answers. There is no charge to attend this class. Video-enabled attendance is available. Patients can access remotely and join from any video-enabled device. To receive the Zoom link to connect to this workshop, please email Renie Anderson @ renieanderson@att.net
Read More About Journey Through Your Cancer: Techniques to Lessen the Side Effects of Radiation Therapy
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19Nov
Renown Institute for Cancer is teaming up with Renie Anderson, a trained and certified expert in cancer treatment side effect management. Attend this workshop in person at Renown Regional or virtually via Zoom to learn mind-body techniques to help you feel more connected and joyful in life as you move beyond cancer. This workshop includes: Emphasizing the importance of identifying resistance. Moving through resistance by understanding the concepts of acceptance and surrender. Identifying goals and visions. Creating action steps to help break patterns, to help you stay in a healthier mindset and feel more calm. There is no charge to attend this class. Video enabled attendance is available. Patients can access remotely and join from any video-enabled device. To receive the Zoom link to connect to this workshop, please email Renie Anderson @ renieanderson@att.net
Read More About Cancer Support Virtual Workshop 3: Thrivorship – After Cancer Care
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19Nov
Renown Institute for Cancer is teaming up with Renie Anderson, a trained and certified expert in cancer treatment side effect management. Attend this workshop in person at Renown Regional or virtually via Zoom to learn mind-body techniques to help you feel more connected and joyful in life as you move beyond cancer. This workshop includes: Emphasizing the importance of identifying resistance. Moving through resistance by understanding the concepts of acceptance and surrender. Identifying goals and visions. Creating action steps to help break patterns, to help you stay in a healthier mindset and feel more calm. There is no charge to attend this class. Video enabled attendance is available. Patients can access remotely and join from any video-enabled device. To receive the Zoom link to connect to this workshop, please email Renie Anderson @ renieanderson@att.net
Read More About Journey Beyond Your Cancer: Thrivorship Workshop
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25Nov
Renown Institute for Cancer is teaming up with Cancer Treatment Expert Renie Anderson, who is trained and certified at managing cancer treatment side effects. You can attend this workshop in person at Renown Regional or virtually via Zoom. This workshop teaches mind-body techniques to help reduce anxiety, feel calmer, visualize your treatment in a healing way and enhance healing through activities that will bring you relief. This workshop includes: Helping patients feel more connected, reducing fight/flight response and assisting patients to feel more at ease. Learning how stress impacts our bodies and our role in taking responsibility as a partner in recovery. A mindfulness relaxation session. Allowing patients to express concerns over their side effects and re-framing for a more positive experience. Open time for questions and answers. There is no charge to attend this class. Video-enabled attendance is available. Patients can access remotely and join from any video-enabled device. To receive the Zoom link to connect to this workshop, please email Renie Anderson @ renieanderson@att.net
Read More About Journey Through Your Cancer: Techniques to Lessen the Side Effects of Radiation Therapy
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