RENOWN NEWSROOM

Clinical researchers with the Healthy Nevada Project co-author research paper with findings that emphasize the need for a comprehensive approach to breast cancer risk assessment – including a focus on genetic medicine – to help ensure that individuals at high risk are identified and supported proactively rather than reactively.  Breast cancer is a leading cause of cancer death among women in the United States. According to the American Cancer Society, about 1 in 8 women will develop breast cancer and about 1 in 39 women will die from breast cancer. Breast cancer is associated with increased age, hereditary factors, obesity, and alcohol use. Since 1990, breast cancer death rates have declined progressively due to advancements in treatment and detection. In Nevada there are an estimated 2,310 new breast cancer cases a year, and genetic mutations such as in the genes BRCA1 or BRCA2 remain a top risk factor for this prevalent disease. Recognizing the urgency for progress in breast cancer research, a collaborative effort between physicians, advanced practice providers and scientists from the Healthy Nevada Project® (HNP) and Helix have unveiled groundbreaking research. This study explores how genetic screenings are a necessary supplement to traditional testing methods, together offering more accurate insights into a patient's likelihood of developing breast cancer in the future. HNP is operated by Renown Genomic Medicine and the Institute for Health Innovation and is one of the largest community-based population health studies in the country. Their team works in collaboration with Helix, a leader in precision health that delivers comprehensive genomic solutions. Together, this dynamic partnership aims to understand breast cancer risk factors and pave the way for more effective preventative measures. The combined research team studied 25,591 female HNP participants to evaluate the performance of different genetic screening approaches to identify women at high risk of breast cancer. The results of this research suggest that a combined monogenic, or single-gene, and polygenic, or multi-gene, approach to breast cancer screenings helped produce more accurate results and more closely identify study participants who have a high genetic risk of developing the disease. "Based on this research, we are advocating a shift in approach which would improve breast cancer risk assessment through a combination of effective family history ascertainment and genetic screening,” said Joseph Grzymski, PhD, principal investigator of the Healthy Nevada Project, research professor at the University of Nevada, Reno School of Medicine and co-author of the breast cancer research paper. “This tailored approach, founded on the assessment of individual genetic risk, not only intends to elevate patient well-being but also will improve efficiency and equity in healthcare." Complementing the team’s research on leveraging genetics to identify women at low genetic risk of breast cancer that could safely defer mammogram screenings by five to 10 years that was released in late 2023 in JAMA Oncology, the study suggests that incorporating genetic information can assist in personalizing breast cancer screenings and optimizing the use of screening resources. "Existing disparities persist across various facets of breast cancer screening and treatment; however, genetic screening is clearly a powerful tool to help facilitate early intervention for those at higher risk,” said Jamie Schnell Blitstein, APRN, a primary care nurse practitioner at Renown Health and co-author of the breast cancer research paper. “By placing a heightened focus on risk, we underscore the pivotal role of preventative breast cancer screening.” Despite the availability of effective methods for early screening, co-authors of this research found that 78 percent of women with a family history of breast cancer had their risk ascertained only after a breast cancer diagnosis. The findings emphasize the need for a comprehensive approach to breast cancer risk assessment – including a focus on genetic medicine – to help ensure that individuals at high risk are identified and supported proactively rather than reactively.  “These findings that can profoundly impact how healthcare is delivered were only made possible by all the participants who were willing to consent to research,” said Alex Bolze, PhD from Helix and co-author of the publication. “Broad-scale collaboration projects like these between Renown Health and UNR that engage large populations where participants share both their genetic information as well as electronic health records drive advancements in preventative medicine, as well as fundamental biological research.”   The research paper was officially accepted on Jan. 29, 2024, and will be published by Elsevier, Inc. on behalf of the American College of Medical Genetics and Genomics. The contents of the paper will appear in the international journal Genetics in Medicine Open. Read the full article by visiting sciencedirect.com. The Healthy Nevada Project is currently recruiting new study participants. Free to all Nevadans with a saliva sample or blood draw, participants and their referring providers receive access to whole-exome sequencing and clinical grade results that help provide insight into their unique genetic risks tied to heart disease and certain cancers. If you are interested in enrolling in the study, schedule a Virtual Consent Appointment through MyChart or contact the Renown Institute for Health Innovation at RenownIHI@renown.org or (775) 982-6914 to be connected to a Genomic Representative. About Renown Health Renown Health is the region’s largest, not-for-profit integrated healthcare network serving Nevada, Lake Tahoe and northeast California. With a diverse workforce of more than 7,000 employees, Renown has fostered a longstanding culture of excellence, determination and innovation. The organization comprises a trauma center, two acute care hospitals, a children’s hospital, a rehabilitation hospital, a medical group and urgent care network, and the region’s largest, locally owned not-for-profit insurance company, Hometown Health. Renown is currently enrolling participants in the largest community-based genetic population health study, the Healthy Nevada Project®. To join the Renown Health team, visit renown.org/careers. About Helix Helix is the leading population genomics and viral surveillance company operating at the intersection of clinical care, research, and data analytics. Helix enables health systems, life sciences companies, payers, and government partners to accelerate the integration of genomic data into patient care and public health decision-making. Learn more at helix.com.

Read More About Research Shows Genetic Approaches to Breast Cancer Screenings Yield More Accurate Results

Renown Health Physical Therapist Dr. Kelly Winkel leads virtual event to connect adults through basic stretching exercises and helpful movement strategies to aid in healthy aging.   To help our 55+ community experience the many benefits of stretching, Renown’s Sterling Silver Club is hosting a free, virtual Rise & Shine Stretches lecture on Wednesday, July 15 from 10-11 a.m. During the live event, Kelly Winkel, doctor of physical therapy for Renown Physical Therapy, will teach attendees the basic principles of exercising as we age and provide a demonstration of gentle stretching and stabilizing exercises to help start the day. She will also share her expertise on some of the common ailments we develop as we age and offer tips for overcoming those ailments.  This virtual event will be hosted via Microsoft Teams. Those interested in attending are asked to RSVP online or call 775-982-7787. A dial-in option is available for individuals who don’t have access to a computer.   “A good morning stretching routine puts the body in motion and has the power to set the tone of your entire day,” said Dr. Winkel. “Plus, stretching becomes even more important as we age and our range of movement lessens and we wake up with more aches and pains. Improved flexibility, balance, muscle control and a reduced risk of injury are just a few of the wellness benefits of routine stretching, all contributing to a healthier lifestyle. There is no better way to start your day than with a few tried-and-true stretches.”  Attendees are encouraged to wear comfortable workout attire and sturdy shoes so they can try the exercises out with the group. They are also invited to ask for clarification or a modification if needed.  Anyone over the age of 55 is invited to join Renown’s free Sterling Silver Club, created to help people live healthy, happy lives every day. The Club is a program of the Renown Institute for Healthy Aging. Members enjoy exclusive benefits all designed with their interests in mind. From social events and lectures to entertainment, special discounts, and health insights and tips, this club is a place for community members to shine and embrace the joys of healthy aging. While the Sterling Silver Club is not currently hosting in-person events during this time, it is hosting educational talks like this one to help aging adults stay healthy through its online channels.  “The last few months have been difficult for many older adults as they stay indoors with little to no in-person contact with their loved ones,” said Tori DellaRocca, who oversees Renown’s Sterling Silver Club loyalty program. “The need to stay connected is more important now than ever. It has been a joy giving our members something to look forward to- a chance to learn, ask questions and share their stories. Seeing everyone tune in from their homes has been a powerful reminder that we truly are all in this together.”      For more information on upcoming virtual events from Renown’s Sterling Silver Club and to sign up, please visit www.renown.org/SterlingSilver.      About Renown Health Renown Health is the region’s largest, locally owned and governed, not-for-profit integrated healthcare network serving Nevada, Lake Tahoe and northeast California. With a diverse workforce of more than 7,000 employees, Renown has fostered a longstanding culture of excellence, determination and innovation. The organization comprises a trauma center, two acute care hospitals, a children’s hospital, a rehabilitation hospital, a medical group and urgent care network, and the region’s largest, locally owned not-for-profit insurance company, Hometown Health. Renown’s institute model addresses social determinants of health and includes: Child Health, Behavioral Health & Addiction, Healthy Aging and Health Innovation. Clinical institutes include: Cancer, Heart and Vascular Heath, Neurosciences and Robotic Surgery. Renown is currently enrolling participants in the world’s largest community-based genetic population health study, the Healthy Nevada Project®. For more information, visit renown.org.

Read More About Sterling Silver Club Hosts Virtual Stretching Lecture for 55+

Renown employees volunteered to reach out to over 2,500 older adults participating in the non-profits’ free Sterling Silver Club. While people of all ages are coping with the challenges of social isolation, there is one group of individuals who may feel especially lonely during these uncertain times—our aging adults. To offer some friendly conversation and answer any questions older adults may have about Renown’s commitment to keeping them safe during the COVID-19 crisis, Renown Health employees are making phone calls to its Sterling Silver Club members. To date, employees have made nearly 1,000 phone calls. Renown is also hosting several virtual events to reach older audiences.  “The human element of connecting with these members is really special,” said Tori DellaRocca, who oversees this loyalty program at Renown. “Many of the people we call live alone and some have no one to check in on them. It has been a pleasure talking to our members; learning more about them and what they’re doing to pass the time, offering ideas to help them stay busy, and assuring them Renown is here to keep them safe. Since launching this campaign back in March, making these phone calls has been a highlight of my day, and I know I’m not alone in feeling this way.”  Anyone over the age of 55 is invited to join Renown’s free Sterling Silver Club, created to help people live healthy, happy lives every day. Members enjoy exclusive benefits all designed with their interests in mind. From social events and lectures to entertainment (virtual for now), special discounts, and health insights and tips, this club is a place for community members to shine and embrace the joys of healthy aging. “I enjoy the lectures,” said Sterling Silver Club member Liz Barnes. “They appeal to my desire to know more and invariably provide an ‘informed’ call to action.” “After the [lecture] on diabetes prevention, I enrolled in the one-year long, Renown-sponsored diabetes prevention program,” said Liz’s husband, Barry. “After the sleep seminar, I changed my bedtime habits.” While the Sterling Silver Club is not currently hosting events in-person, it is hosting educational talks and ways to help aging adults stay healthy through its online channels.  The “Hello Project” is a virtual gathering place for adults 65 and older to focus on health, wellbeing and offer positive social support, made possible by a partnership with Renown Health, Truckee Meadows Healthy Communities and the Washoe County Health District. These virtual gatherings are hosted every Tuesday and Thursday at noon. Community members can learn more here. In addition, the Sterling Silver Club is hosting a Facebook Live event, Is Age Related to Anxiety?, coming up on Tuesday, April 28 from 11 a.m. – noon. During this live event, Renown psychologist Dr. Buddy Coard will discuss the impact of anxiety as we age and what we can do to prevent it from getting in the way of enjoying life. Those interested in attending can RSVP here. “Our members have enjoyed the opportunity to learn from experts in the field of healthy aging as well as connect with their fellow community members,” said DellaRocca. “We’re all in this together, and these virtual events, combined with our phone call efforts, show our older population they truly are not alone.”  For more information on upcoming virtual events from Renown’s Sterling Silver Club and to sign up, please visit www.renown.org/SterlingSilver.      About Renown Health Renown Health is a locally governed and locally owned, not-for-profit integrated healthcare network serving northern Nevada, Lake Tahoe and northeast California. Renown is one of the region’s largest private employers with a workforce of more than 7,000. It comprises three acute care hospitals, a rehabilitation hospital, the area’s most comprehensive medical group and urgent care network, and the region’s largest and only locally owned not-for-profit insurance company, Hometown Health. Renown has a long tradition and commitment to continually improve the care and the health of our community. For more information, visit renown.org.

Read More About The Power of a Phone Call; Renown Health Connects With Community Members 55 and Over