RENOWN NEWSROOM

Clinical researchers with the Healthy Nevada Project co-author research paper with findings that emphasize the need for a comprehensive approach to breast cancer risk assessment – including a focus on genetic medicine – to help ensure that individuals at high risk are identified and supported proactively rather than reactively.  Breast cancer is a leading cause of cancer death among women in the United States. According to the American Cancer Society, about 1 in 8 women will develop breast cancer and about 1 in 39 women will die from breast cancer. Breast cancer is associated with increased age, hereditary factors, obesity, and alcohol use. Since 1990, breast cancer death rates have declined progressively due to advancements in treatment and detection. In Nevada there are an estimated 2,310 new breast cancer cases a year, and genetic mutations such as in the genes BRCA1 or BRCA2 remain a top risk factor for this prevalent disease. Recognizing the urgency for progress in breast cancer research, a collaborative effort between physicians, advanced practice providers and scientists from the Healthy Nevada Project® (HNP) and Helix have unveiled groundbreaking research. This study explores how genetic screenings are a necessary supplement to traditional testing methods, together offering more accurate insights into a patient's likelihood of developing breast cancer in the future. HNP is operated by Renown Genomic Medicine and the Institute for Health Innovation and is one of the largest community-based population health studies in the country. Their team works in collaboration with Helix, a leader in precision health that delivers comprehensive genomic solutions. Together, this dynamic partnership aims to understand breast cancer risk factors and pave the way for more effective preventative measures. The combined research team studied 25,591 female HNP participants to evaluate the performance of different genetic screening approaches to identify women at high risk of breast cancer. The results of this research suggest that a combined monogenic, or single-gene, and polygenic, or multi-gene, approach to breast cancer screenings helped produce more accurate results and more closely identify study participants who have a high genetic risk of developing the disease. "Based on this research, we are advocating a shift in approach which would improve breast cancer risk assessment through a combination of effective family history ascertainment and genetic screening,” said Joseph Grzymski, PhD, principal investigator of the Healthy Nevada Project, research professor at the University of Nevada, Reno School of Medicine and co-author of the breast cancer research paper. “This tailored approach, founded on the assessment of individual genetic risk, not only intends to elevate patient well-being but also will improve efficiency and equity in healthcare." Complementing the team’s research on leveraging genetics to identify women at low genetic risk of breast cancer that could safely defer mammogram screenings by five to 10 years that was released in late 2023 in JAMA Oncology, the study suggests that incorporating genetic information can assist in personalizing breast cancer screenings and optimizing the use of screening resources. "Existing disparities persist across various facets of breast cancer screening and treatment; however, genetic screening is clearly a powerful tool to help facilitate early intervention for those at higher risk,” said Jamie Schnell Blitstein, APRN, a primary care nurse practitioner at Renown Health and co-author of the breast cancer research paper. “By placing a heightened focus on risk, we underscore the pivotal role of preventative breast cancer screening.” Despite the availability of effective methods for early screening, co-authors of this research found that 78 percent of women with a family history of breast cancer had their risk ascertained only after a breast cancer diagnosis. The findings emphasize the need for a comprehensive approach to breast cancer risk assessment – including a focus on genetic medicine – to help ensure that individuals at high risk are identified and supported proactively rather than reactively.  “These findings that can profoundly impact how healthcare is delivered were only made possible by all the participants who were willing to consent to research,” said Alex Bolze, PhD from Helix and co-author of the publication. “Broad-scale collaboration projects like these between Renown Health and UNR that engage large populations where participants share both their genetic information as well as electronic health records drive advancements in preventative medicine, as well as fundamental biological research.”   The research paper was officially accepted on Jan. 29, 2024, and will be published by Elsevier, Inc. on behalf of the American College of Medical Genetics and Genomics. The contents of the paper will appear in the international journal Genetics in Medicine Open. Read the full article by visiting sciencedirect.com. The Healthy Nevada Project is currently recruiting new study participants. Free to all Nevadans with a saliva sample or blood draw, participants and their referring providers receive access to whole-exome sequencing and clinical grade results that help provide insight into their unique genetic risks tied to heart disease and certain cancers. If you are interested in enrolling in the study, schedule a Virtual Consent Appointment through MyChart or contact the Renown Institute for Health Innovation at RenownIHI@renown.org or (775) 982-6914 to be connected to a Genomic Representative. About Renown Health Renown Health is the region’s largest, not-for-profit integrated healthcare network serving Nevada, Lake Tahoe and northeast California. With a diverse workforce of more than 7,000 employees, Renown has fostered a longstanding culture of excellence, determination and innovation. The organization comprises a trauma center, two acute care hospitals, a children’s hospital, a rehabilitation hospital, a medical group and urgent care network, and the region’s largest, locally owned not-for-profit insurance company, Hometown Health. Renown is currently enrolling participants in the largest community-based genetic population health study, the Healthy Nevada Project®. To join the Renown Health team, visit renown.org/careers. About Helix Helix is the leading population genomics and viral surveillance company operating at the intersection of clinical care, research, and data analytics. Helix enables health systems, life sciences companies, payers, and government partners to accelerate the integration of genomic data into patient care and public health decision-making. Learn more at helix.com.

Read More About Research Shows Genetic Approaches to Breast Cancer Screenings Yield More Accurate Results

Renown Health Foundation announced today a special delivery from Sarah Carmona Zink and her Dreams Foundation, donating hundreds of pajamas, receiving blankets, beanie caps, nursing pillows and more, as well as a check for $10,500 for the neonatal intensive care unit (NICU) at Renown Children’s Hospital. Please see visuals to accompany this story here.  For the past three years, Carmona Zink and the Dreams Foundation have staged a fundraisingand baby item drive to give back to the NICU that took care of Carmona Zink’s son, Howie, during a difficult time for the family.  “Our NICU drive is inspired by Howie, who just turned 4,” said Carmona Zink. “Hespent about a month in Renown’s NICU because he was born withgastroschisis, a condition where his intestines formed on the outside of his body.During Howie’s stay, the NICU staff was an extension of our family and cared so deeply for all of us. Our goal through this drive has always been to give back to those who gave so much to us, as well as provide a sense of normalcy to parents with babies in the NICU.During these unprecedented times, providing comfort and relief to parents is more important than ever.” “As a pediatric intensive care physician, who is also a dad, and a new grandfather, I thank Sarah Carmona Zink, her family and the Dreams Foundation for their incredible generosity and compassion. Through the years, Sarah has done so much to support the Renown Children’s Hospital NICU team and other NICU parents- she does so with such joy and enthusiasm, and we are incredibly grateful to her for all that she does,” said Tony Slonim, MD, D.Ph., Renown’s President & CEO. Through this year’s donation drive, Carmona Zink collected the following items for Renown’s NICU:  50 nursing pillows 180 hand-knitted baby beanies 532 pairs of pajamas 682 receiving blankets 8 sleep sacks 473 scent pads, which parents keep on their skin and then leave with their baby so he/she can be comforted by their parents’ scent Books for siblings to read while visiting Miscellaneous items such as pumping storage bottles, bibs, baby hand covers, newborn socks, mobiles, and nursing pillow covers $10,500 monetary donation from the Dreams Foundation   Dr. Max Coppes, Physician-in-Chief of Renown Children’s Hospitaland Larry Duncan, Administrator of Renown Children’s Hospital add, “We are truly blessed with the support for the very smallest residents of Renown Children’s Hospital, some weighing less than a pound! Sarah and her family inspire us to remain devoted to the children we serve, knowing that the community is committed to our Children’s Hospital.” “We look forward to this donation drive every year,” said Renown NICU nurse Jessica Bakke. “The work Sarah and her team do to collect these itemsis very meaningful to all of us. We don’t always have funds to purchase extra items like clothing, blankets and nursing pillows, so everything we receive through this drive makes a differencefor our babies and their families. It is a wonderful gift to be able to offer fresh clothing and other much-needed items to help these parents.”     Greg Walaitis, Chief Development Officer for Renown says, “We are extremely grateful to Sarah and the Dreams Foundation for their generous donation to our NICU. Donations like these help ensure we have plenty of items on hand when our babies and their families need them. This donation allows parents with babies in our NICU to focus solely ontheir baby’s health, rather than material needs that may come up along the way. It is an honor to be the recipient of such an amazing act of kindness for the third year in a row.”     Founded in 2012, Dreams Foundation is a non-profit created to meet the unmet dreams and aspirations of individuals, families, neighborhood churches, people-serving agencies and organizations, recognized charities, boys and girls clubs, and youth sports programs in communities. To learn more, visit dreamsfoundationinc.com.  Ways to Support the Miracles Made Possible at Renown Children’s Hospital Call Renown Health Foundation at 775-982-5545 Make a gift at renown.org/give Mail a check to Renown Health Foundation, 1155 Mill St., O2, Reno, NV 89502 Venmo: @RenownFoundation       About Renown Health Renown Health is the region’s largest, locally owned and governed, not-for-profit integrated healthcare network serving Nevada, Lake Tahoe and northeast California. With a diverse workforce of more than 7,000 employees, Renown has fostered a longstanding culture of excellence, determination and innovation. The organization comprises a trauma center, two acute care hospitals, a children’s hospital, a rehabilitation hospital, a medical group and urgent care network, and the region’s largest, locally owned not-for-profit insurance company, Hometown Health. Renown’s institute model addresses social determinants of health and includes: Child Health, Behavioral Health & Addiction, Healthy Aging and Health Innovation. Clinical institutes include: Cancer, Heart and Vascular Heath, Neurosciences and Robotic Surgery. Renown is currently enrolling participants in the world’s largest community-based genetic population health study, the Healthy Nevada Project®. For more information, visit renown.org.

Read More About Dreams Foundation Makes $10,500 Donation Benefiting NICU Babies