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There are many misconceptions about clinical research, so we have unpacked a few common myths we hear to help you make an informed decision in your healthcare. Misconception #1: If I join a clinical trial, I’ll just be a guinea pig. Quite the opposite is true! Through honest and respectful conversation, we ensure all participants are informed of the benefits and risks associated with the clinical trial during the informed consent process. Being in a clinical trial is voluntary, and we respect our patients’ decision to join or decline to participate in the clinical trial. You can always change your mind at any time as well. When patients join a clinical trial, they receive an additional team of healthcare professionals, including additional physicians, pharmacists and research coordinators, dedicated to their safety and well-being. This means that clinical trial participants often receive more support than they would in the standard treatment setting. Misconception #2: Clinical trials are too dangerous because they use new treatments that haven’t been tested. We recognize that there are different levels of risk associated with participating in a clinical trial depending on the type of study. However, new treatments are only reviewed through clinical trials after they have gone through extensive testing. New treatments that do not show promising results for safety and potential benefit during laboratory testing do not receive approval to begin clinical trials. Your research team reviews any expected benefits and risks identified from previous studies during the informed consent process, as well as any updates that occur throughout the duration of the clinical trial. The research team stays in close contact with you during the entire process, documenting and treating any side effects that you experience for both your safety and the safety of participants like you. Misconception #3: I don't want to join a trial because I could be wasting my time receiving a placebo. A placebo is a substance that has no therapeutic effect, sometimes called a “sugar pill.” Participants who receive a placebo during a clinical trial are very important, helping researchers definitively determine the specific good and bad effects of the new medication. Many clinical trials that involve a placebo also offer what is called an open label extension or cross-over study. Cross-over studies ensure that anyone taking the placebo can begin receiving the new medication, often for several years. Cross-over studies help clinician researchers understand the long-term effects of a medication while also giving patients free access to novel care for several months and even years.

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Participating in a clinical trial is voluntary and a personal choice. Clinical trials are research studies that involve people and are an important part of patient care. What is a clinical trial?  Clinical trials are research studies that involve people, and they are an important part of patient care. There are several different types of clinical trials; some are designed to understand trends in a disease or identify better ways to diagnose a condition, while others determine if a new treatment is safe and works when treating, improving or preventing a health condition. There are over 400,000 clinical trials currently being conducted in the United States, and even more across the world. This includes health conditions such as heart failure, cancer, Parkinson’s Disease, respiratory conditions like COPD, common infections, cystic fibrosis, and many more. Clinical trials lead the healthcare industry to new discoveries that contribute to reliable and exact care, improving healthcare quality and saving lives. Clinical trials are conducted by a team of researchers, including doctors, pharmacists and clinical research coordinators. These research teams are highly skilled in their specialty areas, often providing traditional patient care and seeing research patients in the same day. These teams are responsible for making sure the clinical trial is completed correctly, and their patients are their top priority. Why should I consider participating in a clinical trial? Participating in a clinical trial is voluntary and a personal choice. There are many reasons why patients decide to get involved in clinical research. While many clinical trials are designed for patients who have a certain health condition, many studies also ask healthy volunteers to contribute in order to compare health outcomes. Clinical trials are also for patients at all different stages of their diagnosis. Depending on the specific study, the patient may receive access to a new cutting-edge treatment before it is widely available. When patients join a clinical trial, the research team becomes a health partner dedicated to their health and well-being. When patients join a clinical trial, they make an informed decision in their healthcare by weighing all available options in addition to routine treatments. Research participants know that they are contributing meaningfully and helping other patients like them. Where can I find more information about clinical trials at Renown Health? Renown Health’s mission is to make a genuine difference in the health and well-being of the communities we serve. Renown’s clinical trial portfolio offers leading care options to patients in northern Nevada, close to home, in a variety of specialties. Contact the Renown Clinical Research Office for more information on clinical trials available to you!

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Renown Health, the region's leading cardiology care provider, is offering a clinical trial for eligible patients struggling to control their high blood pressure. Nearly half of adults (119.9 million) in the United States have hypertension, or blood pressure that is higher than normal. Hypertension can put you at risk of other life-threatening disease, such as a heart attack or stroke. There are methods that cardiologists use to manage high blood pressure, but only 1 in 4 adults with hypertension (27.0 million) have their blood pressure under control.* Some patients with high blood pressure experience resistant hypertension, which does not respond well to multiple antihypertensive medications given at the same time. This means that there are many important opportunities for healthcare professionals to explore new ways to treat hypertension.  At Renown Health, we lead the region in cardiology care with our technological expertise and patient-centered approach. That is why our cardiology team is partnering with the Renown Research Office to offer the RADIANCE Continued Access Protocol (RADIENCE CAP) clinical trial to eligible patients. RADIANCE CAP is a non-randomized study designed to allow for continued access to ultrasound renal denervation therapy via the Paradise System, and to allow for the on-going collection of safety and effectiveness data in patients with uncontrolled hypertension despite the prescription of antihypertensive medications. The body’s complex communication system between the brain, heart and kidneys can sometimes become overactive, increasing your blood pressure through messages in the nervous system. Renal denervation is a minimally-invasive procedure which reduces activity from the nerves in your kidneys to lower blood pressure.  This is the third in a series of renal denervation clinical trials Renown Health has offered to patients with resistant hypertension over the last several years, with over 40 local participants.  “All the participants that I have had the pleasure to work with on these studies are very excited and grateful to have this option for helping control their blood pressure” states Lisa English, Lead Clinical Research Coordinator for Cardiology studies at Renown Health. “I love getting to know each one of them and helping on their healthcare journey. We have an amazing team of providers and staff at Renown that go out of their way to make patients experiences positive and the studies successful.” Dr. Michael Bloch, Cardiologist and Principal Investigator for the RADIANCE CAP study at Renown Health’s Institute for Heart and Vascular Health adds, “Despite lifestyle modifications like diet and exercise and the widespread availability of effective and well-tolerated medications, approximately 50% of all people with hypertension have inadequate blood pressure control putting them at risk for stroke, heart failure and kidney disease. As a one-time durable procedure, renal denervation with the Paradise endovascular system from ReCor Medical, Inc. may help millions of patients improve their blood pressure control without necessarily needing to increase their medications.” Our teams of expert providers and researchers are here to support you on your healthcare journey. Talk to your provider about the RADIANCE CAP clinical trial at your next appointment to see if participation may be right for you.

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Michael Millman was all set to move to Reno from the Bay Area when he noticed a pimple-like growth on his forehead, and he decided to get biopsied "just in case." It was July 2020, less than six months into the COVID-19 pandemic, when Michael got the call that the biopsy came back cancerous. He was in shock. Still living in the Bay Area at the time, he immediately scheduled to have the basal cell carcinoma removed in August. After the removal, he thought he was in the clear, but a few months later, Michael noticed that his lymph nodes felt weird, and he even cut himself shaving because of some persistent swelling in the area. Given his recent history of skin cancer, Michael immediately scheduled an appointment with a specialist in the Bay Area. "I met with an ear, nose and throat doctor who suggested a fine needle biopsy of my lymph nodes, tongue and an MRI, both with and without contrast," Michael said. "I remember feeling dreadful and that I couldn't believe this was happening yet again." A Hard Decision Michael's squamous cell carcinoma, determined by the pathology report to be significantly influenced by the HPV virus, had metastasized to his lymph nodes on both sides of his neck, and his doctor said it could be stage four cancer. He remembers feeling like he was in quicksand, unsure if he should follow through with his move to Reno, or stay in the Bay Area for treatment. By now, it was early December 2020, and hospitals in the Bay Area and across the world were at limited capacity due to COVID-19. But, in what Michael describes as a positive twist of fate, the San Francisco ear, nose and throat provider he had seen about his biopsy results mentioned that he knew many providers in the oncology department at Renown, including Abhinand Peddada, MD. The San Francisco provider called Dr. Peddada's office with a referral, and Michael even remembers that Renown called him to hear more about his diagnosis before he even got the chance to call them "To be honest, I was feeling shut out in the Bay Area, and Dr. Peddada said he could help me expedite the treatment process," Michael said. "I finally felt a sense of relief." And so began Michael's 7-week chemoradiation cancer treatment program at Renown.

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There are nearly 1 million adults living with MS in the United States alone. For comparison, that is roughly the entire population of the Reno/Sparks and Las Vegas areas combined. MS is a neurological autoimmune condition which means that the immune system of patients with MS attacks the body’s myelin, a protective substance that covers your nerves. When this happens, the unprotected nerves can be damaged. Patients with MS may experience many different symptoms ranging from mild to severe, such as mobility and vision problems, fatigue and difficulty thinking. MS is usually diagnosed between the ages of 20-50, but late onset MS can occur in patients over 50 years old. While there is no cure for MS, there are effective treatments that can help reduce the burden of patients’ symptoms and create a positive quality of life. At Renown Health, we have joined the fight against MS through a partnership between advanced neurology programs and providers and our research office. We are proud to offer newly diagnosed MS patients the opportunity to choose between standard care treatment options or participating in an open label clinical trial, the AGNOS study. This study is assessing the impact of a new medication, ofatumumab, as the first disease modifying therapy participants receive for managing relapsing remitting MS, the most common form of MS.

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It is no secret that looking for a new job can be stressful and overwhelming. Yet a record number of Americans are quitting their jobs to look for new opportunities, a trend also known as the “Great Resignation.” While there are many reasons why someone might be on the hunt for new work, it’s important for all job hunters to check in with their mental health regardless of their job hunting circumstances. To learn more about maintaining your mental health while looking for a new job, we spoke to Dr. Mavis Major, a Licensed Clinical Social Worker and Behavioral Health Therapist at Renown Health. 1. Identify Goals When beginning your job-hunting journey, your first step should be to make a plan that focuses on quality over quantity. Make lists of companies you would like to work for and, if you’re looking to change fields or industries, make a list of careers that interest you. At this stage in the process, it’s also important to determine what salary range you’re looking for, what type of work environment you want (in-person, remote or hybrid) and understand what benefits are important to you. Identifying goals makes it easier to narrow down the list of jobs you apply for so you can produce quality applications rather than frantically applying for jobs without putting thought into the process. 2. Set Boundaries It does not matter if you are working full-time while applying for jobs or if applying is your job right now; it can be easy to get lost in the stress of it all. For that reason, it is essential to set intentional boundaries throughout the process. This can look like scheduling days that you fully take off from the job search or going for a walk before a big interview to clear your head. Setting boundaries will make you more productive overall and hopefully help you get your mind off the process. 3. Ask For Help Do not try and tackle this undertaking on your own. Once you have identified goals (see tip #1) make lists of people you know within those industries, and do not be afraid to reach out. Of course, never be afraid to reach out to a mental health professional to talk through why this process might be making you feel anxious. Talking to someone who is not your friend or family can give you a different perspective.

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Austin was five years old when he was diagnosed with leukemia. A fever and pale looking skin prompted his mom, Brenda, to bring him into his primary care physician in Carson City. After doing some blood work, the fight to beat Austin's cancer began. The initial shock of learning your child has cancer is traumatic and can feel like a whirlwind. Then the questions begin – will my child survive, what happens next, how will we tell his siblings, will we have to travel out of state for quality care? The list of questions feel endless. While grappling with the news, Brenda brought Austin to Renown Children’s Hospital for an additional check-up. This weeklong hospitalization started with a series of tests to confirm Austin’s diagnosis and ultimately it led to treatment for the leukemia. Dr. Jacob Zucker, a pediatric oncologist at Renown Children's Hospital, was with Austin every step of the way, even meeting him in the parking garage on his first day of treatment. Brenda is eternally grateful that Dr. Zucker was on staff at Renown Children's Hospital, which allowed them to keep Austin's care in Reno. The alternative was to travel out of state for care. "Dr. Zucker was the best thing to ever happen to our family. I consider him a part of our family now," said Brenda. "His kindness and knowledge gave us faith in him." Treatment for Childhood Leukemia Austin’s treatment was broken into a number of stages with the first eight months of therapy being the hardest. He would receive almost weekly therapy at Renown Children’s Infusion Center as well as frequent spinal taps with chemotherapy. After eight months, and for the next three years, Austin would receive a maintenance phase therapy. This meant oral chemotherapy every day, IV chemotherapy once a month, spinal chemotherapy every three months and steroids for the first five days of every month. After more than four years of fighting cancer, Austin, now 10, is free of any disease. Currently, he has blood work every two months to ensure he is on the right track. Seeking Advice from Children’s Oncology Groups Throughout Austin's treatment, Brenda regularly sought advice from Children's Oncology Group (COG) members. COG is the world’s largest organization devoted exclusively to childhood cancer. Renown Children's was not a member of COG at the time of Austin's treatment -- with the closest facilities located in the Bay Area and Salt Lake City – but it is /now. “When faced with pediatric cancer, the last thing parents should worry about is traveling great lengths to receive the best in cancer care," said Larry Duncan, Vice President of Pediatrics and Surgery and Administrator at Renown Children's Hospital. "We are proud to now offer the most advanced childhood cancer treatment options here at Renown, close to home and convenient for area patients and their families.” This membership allows Renown to enroll our youngest patients – just like Austin – in the latest clinical trials, including groundbreaking treatments, studies to understand these diseases better and in addition, this program will focus on supportive care and survivorship. "The COG allows Renown providers to access treatment plans that were not available to non-COG hospitals when Austin was receiving treatment," said Brenda. "It comforts me to know that not only can children receive cancer treatment right at home, but their parents can now elect for them to participate in trials and plans that are at the forefront of cancer treatment today." How You Can Help Make a Difference Renown Health is focused on being the destination for all your family’s health and healthcare needs. As a not-for-profit health system, Renown relies heavily on community funding. If you are interested in supporting Renown Health, and kids like Austin, please consider giving to Renown Health Foundation. Donations are accepted through the following ways: Make a gift at www.renown.org/give Call Renown Health Foundation at 775-982-5545 Mail a check to Renown Health Foundation, 1155 Mill St., 02, Reno, NV 89502

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