RENOWN NEWSROOM

Healthy Nevada Project’s community-based approach reveals up to 90% of CDC Tier 1 genetic condition risks missed using clinical care guidelines. In a new study published today in the journal Nature Medicine, researchers behind the Healthy Nevada Project® suggest that community-based genetic screening has the potential to efficiently identify individuals who may be at increased risk for three common inherited genetic conditions known to cause several forms of cancer and increased risk for heart disease or stroke. In 2018, the Healthy Nevada Project® (the largest, community-based population health study combining genetic, clinical, environmental and social data) started notifying consenting study participants who have certain genetic variants which predispose them to the Centers for Disease Control and Prevention (CDC) Tier 1 genetic conditions. The study focused on identifying carriers of these conditions, which include Hereditary Breast and Ovarian Cancer, Lynch Syndrome, and Familial Hypercholesterolemia, because they are the most common conditions and early detection and treatment could significantly lower morbidity and mortality. Initial results from almost 27,000 study participants showed that 90% of carriers of the CDC Tier 1 genetic conditions were not previously identified in a clinical setting. The authors conclude that population genetic screening would identify at-risk carriers not identified during routine care. “Our first goal was to deliver actionable health data back to the participants of the study and understand whether or not broad population screening of CDC Tier 1 genomic conditions was a practical tool to identify at-risk individuals,” explained Joseph Grzymski, Ph.D., the principal investigator of the Healthy Nevada Project®, a research professor at the Desert Research Institute (DRI), chief scientific officer for Renown Health and lead author of the study. “Now, two years into doing that, it is clear that the clinical guidelines for detecting risk in individuals are too narrow and miss too many at risk individuals.” Within the group of 26,906 Healthy Nevada Project® participants that Grzymski’s research team studied, 358 (1.33%) were carriers for CDC Tier 1 conditions. However, only 25% of those individuals met clinical guidelines for genetic screening. Additionally, more than 20% of the carriers already had a diagnosis of disease relevant to their underlying genetic condition. “We’re at a point now where it’s possible to do clinical-grade genetic screening at population-scale,” added James Lu, M.D. Ph.D., co-founder and chief scientific officer of Helix and senior co-author of the study. “What this study demonstrates is the potential impact of doing so. By making genetic screening available more broadly, we can help the millions of Americans who are unaware that they are living at increased risk for highly actionable, genetic conditions take action.” Most notably, the study found that of the 273 participants who were carriers of the CDC Tier 1 genetic conditions and had clinical record information, only 22 individuals showed any previous suspicion of their underlying genetic conditions. “For the first time, we are providing information at the individual level so study participants can make lifesaving changes to reduce their risk based on their genetics,” said Anthony Slonim, M.D., Dr.PH., FACHE, president and CEO of Renown Health and co-director of the Project® study. “We’re conducting research on the community level to develop leading-edge research on health determinants for entire neighborhoods, states and eventually, the country. Returning these results allows us to understand the prevalence of genetically programmed diseases and illnesses that we have here in Nevada and ensure we are providing the best prevention and care plans. For the individual, the return of results can be life changing.” According to the CDC, early detection and intervention of the Tier 1 genetic conditions could have a meaningful potential for clinical action ability and a positive impact on public health. The Healthy Nevada Project®, which launched in 2016, offers free genetic testing to every Nevadan, aged 18 and older, interested in learning more about their health and genetic profile. With more than 50,000 study participants enrolled in four years, the Healthy Nevada Project® has become the fastest-enrolling genetic study in the world. For more about the Healthy Nevada Project® please visit healthynv.org     Renown Institute for Health Innovation is a collaboration between Renown Health – a locally governed and locally owned, not-for-profit integrated healthcare network serving Nevada, Lake Tahoe and northeast California; and the Desert Research Institute – a recognized world leader in investigating the effects of natural and human induced environmental change and advancing technologies aimed at assessing a changing planet. Renown IHI research teams are focused on integrating personal healthcare and environmental data with socioeconomic determinants to help Nevada address some of its most complex environmental health problems; while simultaneously expanding the state’s access to leading-edge clinical trials and fostering new connections with biotechnology and pharmaceutical companies. Learn more at Healthynv.org. Helix is the leading population genomics company operating at the intersection of clinical care, research, and genomics. Its end-to-end platform enables health systems, life sciences companies, and payers to advance genomic research and accelerate the integration of genomic data into clinical care. Powered by one of the world's largest CLIA / CAP next-generation sequencing labs and its proprietary Exome+Ⓡ assay, Helix supports all aspects of population genomics including recruitment and engagement, clinically actionable disease screening, return of results, and basic and translational research. In response to the COVID-19 public health crisis, Helix has launched a sensitive and scalable end-to-end COVID-19 test system to meet the needs of health systems, employers, governments, and other organizations across the country. Learn more at www.helix.com.

Read More About Population Genetic Screening Show to Efficiently Identify Increased Risk for Inherited Disease

Presented by the Desert Research Institute and Renown Health, DANA will help people learn more about the Healthy Nevada Project® and their own unique, genetic health traits What is the Healthy Nevada Project®? What are the benefits of joining this research study? How can I find out if I carry genes for health risks like heart disease, hereditary breast and ovarian cancer syndrome and Lynch syndrome? What if a holographic avatar, powered by artificial intelligence (AI), could answer all these questions and more? DANA has all the answers, she is a virtual assistant with “DNA” in her name, presented by the Renown Institute for Health Innovation (Renown IHI), a collaboration between Renown Health and the Desert Research Institute (DRI). This life-sized, holographic avatar will greet individuals outside Renown Regional Medical Center’s Sierra Café, and talk to them about the Healthy Nevada Project, the world’s largest community-based genetic population health study. Members of the media are invited to meet DANA this morning from 10 a.m. – noon. Please reply to this email or call (775) 691-7308 to coordinate a meet and greet. “Unfortunately, Nevada ranks among the lowest in the nation for health outcomes—and we are working to change that,” said Anthony Slonim, M.D., D.Ph., president and CEO of Renown Health and president of Renown Institute for Health Innovation. “Through the Healthy Nevada Project® , our goal is to offer genetic testing to every Nevadan interested in learning more about their health and genetic profile. Thanks to this advanced technology, DANA will offer people a personalized explanation of the Project, and help them take the next step to better understand their health, and their health risks, so they can modify their behavior and ultimately, live a healthier, happier life.” With more than 51,000 study participants enrolled to date, the Healthy Nevada Project® is considered the fastest-enrolling genetic study in the country. The Project is also the first of its kind to return clinical results to study volunteers, which means participants can learn their genetic risks tied to heart disease and certain cancers, as well as lifestyle changes that could potentially help reduce their risk and prevent disease. Furthermore, participants can choose to share their information with their medical provider to improve and enhance their medical care. “We are always happy to engage with our study participants and look forward to having them meet and engage with DANA,” said Joseph Grzymski, Ph.D., research professor at DRI, principal investigator of the Healthy Nevada Project® and chief scientific officer for Renown Health. “At a time of physical distancing and limiting human contact where possible, using tools like an avatar and AI are important for communicating, whether it be for genetics, vaccinations or other important health information.” Visitors can interact with DANA through a touch screen (cleaned and sanitized after every encounter) to learn more about the study, enter their contact information and schedule an appointment to join the free genetics study or receive more information about their test results. Kiosk visitors are asked to maintain physical distance guidelines and use the hand sanitizer and Sani Wipes available next to the kiosk.     Renown Institute for Health Innovation is a collaboration between Renown Health - a locally governed and locally owned, not-for-profit integrated healthcare network serving Nevada, Lake Tahoe and northeast California; and the Desert Research Institute - a recognized world leader in investigating the effects of natural and human-induced environmental change and advancing technologies aimed at assessing a changing planet. Renown IHI research teams are focused on integrating personal healthcare and environmental data with socioeconomic determinants to help Nevada address some of its most complex environmental health problems; while simultaneously expanding the state’s access to leading-edge clinical trials and fostering new connections with biotechnology and pharmaceutical companies. Learn more at healthynv.org.

Read More About Introducing Dana Renown Institute for Health Innovations New Life Sized Holographic Kiosk

Renown Health, in keeping with its mission, vision and values and the organization’s long-standing commitment to addressing the social determinants of health, today announced its support of $145,000 to 55 nonprofit organizations with projects aiming to increase the presence and participation of women, racial and ethnic minorities, LBGTQ+ people, people with disabilities, people of low socioeconomic status, and other underrepresented groups. “Improving the health of our community is the foundation of our work. Our mission, vision and values are the essence of what makes us Renown. We are committed to fostering an environment of diversity, inclusion and cultural competence where all are appreciated, fully engaged and motivated to make a genuine, positive difference in the health and well-being of the people and communities we serve,” said Tony Slonim, MD, D.Ph., Renown’s President & CEO. Annie Zucker, manager of community impact at Renown adds, “Social determinants of health have a major impact on health outcomes—especially for the most vulnerable populations. I am proud that Renown, as a not-for-profit healthcare organization, considers social determinants of health to enable more compassionate and comprehensive healthcare for the patients and families we serve.” The following organizations applied for and were awarded Diversity and Inclusiveness financial grants today from Renown Health:   Urban Roots   Diversity and Inclusion in the Garden Sierra Nevada Ballet  Free BOYS ONLY BALLET  Eddy House Eddy House- Children's Cabinet (EHCC) Outreach Boost   Terry Lee Wells Nevada Discovery Museum  The Discovery's Cultural Competence Learning Institute    Communities In Schools of Western Nevada   CIS of Nevada Diversity, Equity and Inclusion Change Team  Dress for Success Reno -   Northern Nevada Professional Women's Group  Nevada Elite Wrestling  Nevada Elite Girls Youth Wrestling  Arts for All  Nevada Artist in Residency Program   Community Health Alliance  Conveying CHA Values in New Employee Orientation   Forever 14  Empowering Teens to Go Above & Beyond Experiential   Spread The Word Nevada  Building Home Libraries- Diversity, Culture & Inclusion  Head Injury Association of Northern Nevada  Physical Fitness Training for Traumatic Brain Injured Survivors  Urban Lotus Project  Urban Lotus Project - Service Staff Training Program   The Zawadisha Fund  We Are Change Makers   Tyler Robinson Foundation  Family Financial Grant Program   Note-Able Music Therapy Services    Improving Cultural Responsiveness & Organizational Diversity Achievement Beyond Obstacles - Reno-Sparks Rotary District 5190  Achievement Beyond Obstacles Leadership Academy  Nevada Volunteers   Inclusion Begins with Removing Language Barriers  Special Olympics Nevada  Special Olympics Nevada  Awaken   The Awaken Drop-In Center Nevada Humanities  Democracy and the Informed Citizen: An Online Salon Series   Nevada Gay Men's Chorus  Happy Holiday's, a Welcome Back Concert  Big Brothers Big Sisters of Northern Nevada   General Mentoring Program High Sierra Industries,  Inc . X-treme Ability Challenge  Junior League of Reno  Safe Embrace Children's Playroom  ReDirect Youth Outreach  ReDirect Youth Outreach & Boxing   Boys & Girls Clubs of Western Nevada  Positive Action for Low-Moderate Income Youth   Domestic Violence Resource Center Domestic Violence Resource Center American Cancer Society Nevada HPV Cancer Prevention Collaborative Reno Cancer Foundation Reno Cancer Foundation under served population grant Pinocchio's Moms on the Run Pinocchio's Moms on the Run Temple Sinai Reno Access for All Sierra Arts Foundation Road Maps The All Of Us Project Reno-Sparks Negro Business & Professional Women's Clubs, Inc. Reno-Sparks Negro Business & Professional Women's Club Sierra Nevada Journeys Sierra Nevada Journeys’ Community Needs Assessment Sierra Nevada Journeys Sierra Nevada Journeys’ Community Needs Assessment Reno Little Theater Reno Little Theater- IDEA Grant Reno Little Theater Reno Little Theater- IDEA Grant High Fives Nonprofit Foundation Peer Mentorship Program High Fives Nonprofit Foundation Peer Mentorship Program Nevada Diabetes Association Changing Outcomes for Young Adults  Nevada Diabetes Association Changing Outcomes for Young Adults  Sky Tavern Sky Tavern Ability Sports Day Sky Tavern Sky Tavern Ability Sports Day Reno Bike Project Future Cycle Tu Casa Latina Outreach to Underserved Communities Sierra Association of Foster Families CELEBRATING THE HOLIDAYS WITH HEALTHY BODIES! Women and Children's Center of the Sierra Regrouping and Moving Forward during the Pandemic Ridge House, Inc. Health Literacy & Recruitment of Underrepresented Groups Alzheimer's Association Latino Outreach/Spanish Speaking Caregiver Support Group On Common Ground -at-Home Kits for the Heart of Community Program On Common Ground Cook-at-Home Kits for the Heart of Community Program University Studies Abroad Consortium Renown Health Diversity & Inclusion Study Abroad Scholarship University Studies Abroad Consortium Renown Health Diversity & Inclusion Study Abroad Scholarship University of Nevada, Reno Foundation Building Inclusivity through Recovery Collaboration University of Nevada, Reno Foundation Building Inclusivity through Recovery Collaboration University of Nevada, Reno Foundation Northern Nevada Latino Health Assessment University of Nevada, Reno Foundation Northern Nevada Latino Health Assessment Catholic Charities of Northern Nevada Feeding the Hungry Reno Sparks NAACP Northern Nevada Minority Health Symposium Sierra Kids Foundation Sierra Kids Foundation ACCEPT Positive Action & Health Education Risk Reduction for HIV.AIDS Northern Nevada Literacy Council Empowerment through Literacy and Education Scholarship United Way of Northern Nevada and the Sierra Equity Learning Community Nevada Volunteers Inclusion Begins Removing Language Barriers     Renown Health issued a request for proposals on June 18 and had anticipated funding 8 organizations. The employee Diversity, Equity and Inclusion Committee was impressed by the community response and Dr. Tony Slonim, president and CEO, chose to support all 55 applications. He notified all not-for-profit agency leaders today in a virtual meeting. Members of Renown Health’s Diversity & Inclusion Committee include: Mitch Harper, Gretna Canterbury Amber Marraccini, Rebecca Doheny, Sean Savoy, Savanah Gonzalves, Jen Walker, Barbara Mader Scherrer, Kristy Cahoon, Katie Mercer, Kara Martinezmoles, Julia Page Hensen, Annie Zucker, Meghan Meagher, Michelle Hernandez, Vivian Cruz, Mary-Ann Brown, Julia Miod and Heather Bridges. As non-profit hospitals, Renown must meet community benefit requirements to qualify for tax-exempt status, this includes funding programs that respond to public health needs and improve overall community health.     About Renown Health Renown Health is the region’s largest, locally owned and governed, not-for-profit integrated healthcare network serving Nevada, Lake Tahoe and northeast California. With a diverse workforce of more than 7,000 employees, Renown has fostered a longstanding culture of excellence, determination and innovation. The organization comprises a trauma center, two acute care hospitals, a children’s hospital, a rehabilitation hospital, a medical group and urgent care network, and the region’s largest, locally owned not-for-profit insurance company, Hometown Health. Renown’s institute model addresses social determinants of health and includes: Child Health, Behavioral Health & Addiction, Healthy Aging and Health Innovation. Clinical institutes include: Cancer, Heart and Vascular Heath, Neurosciences and Robotic Surgery. Renown is currently enrolling participants in the world’s largest community-based genetic population health study, the Healthy Nevada Project® . For more information, visit renown.org.

Read More About Renown Awards Grants to 55 Area Organizations Addressing Diversity and Inclusiveness