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  3. EAY191/ComboMATCH Screening Trial

Molecular Analysis for Combination Therapy Choice

Short Title: EAY191/ComboMATCH Screening Trial


Enrollment Status: Recruiting

NCT #: NCT05564377

Specialty Area: Oncology

Conditions Studied: Solid Tumors; Breast Cancer; Ovarian Cancer; Endometrial Cancer; Fallopian Tube Cancer; Peritoneal Cancer; HER2-negative Breast Carcinoma; Other Unresectable, Recurrent, or Metastatic Solid Tumors

Age Groups: Adult; Older Adult

Phase: Not Applicable


Study Information

Summary / Purpose

To identify patients with advanced solid tumors who may benefit from targeted therapies based on tumor genetic alterations. This screening trial serves as the entry point to multiple ComboMATCH treatment trials.

Study Type: Observational
Accepts Healthy Volunteers: No

Who Can Participate

Eligibility Criteria:
  • Adults 18+ years of age
  • Diagnosed with solid tumor cancer that has spread to nearby tissue or lymph nodes (locally advanced) or to other places in the body (metastatic)
  • Disease progression after at least one prior systemic therapy, or no standard treatment available
  • Tumor must be accessible for biopsy
  • Adequate organ function

What's Involved

Participation in the study will include:
  • Tumor biopsy and genetic testing to identify actionable mutations
  • Blood and tissue samples for biomarker analysis
  • Complete imaging (CT, MRI, PET) and cardiac function tests as needed
  • ComboMATCH treatment trial based on genetic findings, if eligible

Principal Investigator

Additional Information

Location: Renown Health, Office of Clinical Research
Address:

1500 E 2nd St. Reno, NV 89502

General Research: 775-982-3646
Oncology Research: 775-982-5050
Email: Renown-CRD@renown.org

Complete Study Details: https://clinicaltrials.gov/study/NCT05564377

Disclaimer: This listing gives you general information about the study and isn't part of the official consent process. If you decide to learn more, the research team will talk with you and check if you meet any additional requirements to join the study.

ER Wait Times

How are wait times calculated?

Our estimated ER wait times reflect the average time from check-in to being seen by a medical professional during triage, where patients are prioritized based on the severity of their condition.

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