Systemic Therapy With or Without Hepatic Arterial Infusion for Unresectable Colorectal Liver Metastases: The PUMP Trial

The purpose of this study is to compare the usual treatment alone to using hepatic artery infusion chemotherapy plus the usual treatment. The study doctors will be looking to see if hepatic artery infusion chemotherapy increases the life of patients by 12 months or more compared to the usual approach.

• Adults 18+ years of age
• Confirmed unresectable liver confined metastatic colorectal cancer
• Must not have a liver tumor burden exceeding 70% of total liver volume

• Random assignment to receive either standard chemotherapy alone given intravenously (IV), or standard chemotherapy given intravenously (IV) plus pump chemotherapy (Floxuridine) delivered directly into the liver
• Surgery to place the hepatic arterial infusion (HAI) pump, a device that carries chemotherapy through a catheter directly into the liver, for participants assigned to that group
• A single photon emission computed tomography (SPECT) scan combined with a computed tomography (CT) scan after the pump is placed, to check that it is working correctly, for participants assigned to that group
• CT scans throughout the study