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Nivolumab Plus Usual Treatment for People With Advanced Stomach or Esophageal Cancer

Short Title: S2303/PARAMUNE


Enrollment Status: Recruiting

NCT #: NCT06203600

Specialty Area: Oncology

Conditions Studied: Stomach/Gastric Adenocarcinoma; Esophageal Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma

Age Groups: Adult; Older Adult

Phase: II/III


Study Information

Summary / Purpose

To find out if adding nivolumab to the usual second-line treatment (paclitaxel and ramucirumab) helps people with advanced stomach or esophageal cancer live longer, feel better, and delay cancer progression.

Study Type: Interventional
Accepts Healthy Volunteers: No

Who Can Participate

Eligibility Criteria:
  • Adults 18+ years of age
  • Must have received prior immunotherapy (PD-1/PD-L1 inhibitor) and platinum-based chemotherapy
  • HER2-negative and microsatellite stable tumors
  • PD-L1 Combined Positive Score (CPS) ≥ 1
  • No active autoimmune disease
  • No prior severe immune-related adverse events

What's Involved

Participation in the study will include:
  • An intravenous (IV) infusion of the study medication where one group receives the usual cancer treatment (paclitaxel and ramucirumab) and the other group receives the same treatment plus a new medicine called zancombilimab.
  • CT/MRI of chest, abdomen, and pelvis to measure the cancer's reponse to treatment
  • Electrocardiogram (ECG) to measure the electrical activity of your heart
  • Blood and urine samples
  • Questionnaires

Principal Investigator

Additional Information

Location: Renown Health, Office of Clinical Research
Address:

1500 E 2nd St. Reno, NV 89502

General Research: 775-982-3646
Oncology Research: 775-982-5050
Email: Renown-CRD@renown.org

Complete Study Details: https://clinicaltrials.gov/study/NCT06203600

Disclaimer: This listing gives you general information about the study and isn't part of the official consent process. If you decide to learn more, the research team will talk with you and check if you meet any additional requirements to join the study.

ER Wait Times

How are wait times calculated?

Our estimated ER wait times reflect the average time from check-in to being seen by a medical professional during triage, where patients are prioritized based on the severity of their condition.

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