Evaluation of Provider vs. Patient Mediated Cascade Genetic Testing of First-Degree Relatives of Patients With Newly Diagnosed Colorectal Cancer

This clinical trial compares patient (proband)-mediated communication to provider-mediated communication for improving genetic testing in first-degree relatives of patients with newly diagnosed colorectal cancer.

• Adults 18+ years of age
• Newly diagnosed primary colorectal adenocarcinoma, Stage I to IV
• Have not received germline testing in the 2 years prior to enrollment or known hereditary colon cancer syndromes
• Must have at least 2 living first-degree relatives
• No known diagnosis of dementia or cognitive impairment

• Pre-test genetic education
• Genetic testing
• Sharing your cancer diagnosis with your first-degree relatives (FDRs)
• Providing the names and phone numbers of at least two of your living FDRs who are age 18 or older
• Participants whose genetic test is abnormal with the mutation that may cause cancer will be assigned to:
  • The usual approach (Group 1) where you will contact your first-degree family members to recommend them to have genetic testing, or
  • The provider-mediated approach (Group 2) where a study team member will contact your first-degree family members to recommend and assist scheduling their genetic testing.